Human NPC1L1 full length protein-synthetic nanodisc

Human NPC1L1 full length protein-synthetic nanodisc

Catalog Number:
P001561737DIM
Mfr. No.:
FLP100089
Price:
$1,013
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      • Overview

        • Target: NPC1L1
          Tag: C-Flag Tag
          Synonyms: LDLCQ7; NPC11L1; SLC65A2
          Protein Families: Druggable Genome, Transmembrane

          Please contact us at for specific academic pricing.

          Background

          The protein is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length NPC1L1 protein has a MW of 148.7 kDa
          Expression system
          HEK293

          More Information

          UniProt
          Q9UHC9

          * For research use only.

    MSDS

    Documents

    Datasheet

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