Human MDR-1 full length protein-synthetic nanodisc

Human MDR-1 full length protein-synthetic nanodisc

Catalog Number:
P001561707DIM
Mfr. No.:
FLP100029
Price:
$1,013
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      • Overview

        • Target: MDR-1
          Tag: C-Flag Tag
          Synonyms: ABCB1; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1
          Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
          Protein Pathways: ABC transporters

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          Background

          The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length MDR-1 protein has a MW of 141.5 kDa
          Expression system
          HEK293

          More Information

          UniProt
          P08183

          * For research use only.

    MSDS

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