Human CCR2 full length protein-synthetic nanodisc

Human CCR2 full length protein-synthetic nanodisc

Catalog Number:
P001561708DIM
Mfr. No.:
FLP100028
Price:
$1,013
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      • Overview

        • Target: CCR2
          Tag: C-Flag Tag
          Synonyms: CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
          Protein Families: Druggable Genome, Transmembrane
          Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction

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          Background

          The protein is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length CCR2 protein has a MW of 41.9 kDa
          Expression system
          HEK293

          More Information

          UniProt
          P41597

          * For research use only.

    MSDS

    Documents

    Datasheet

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