Human IL-12 p70 ELISA Kit

Interleukin-12 Subunit Beta; Il-12b; Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit; Clmf P40; Il-12 Subunit P40; Nk Cell Stimulatory Factor Chain 2; Nksf2

Uniprot ID: MMP15_HUMAN ; Reactome: R-HSA-6783783 ; Gene ID: 3593 ; Gene Symbol: IL12B

Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.