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Overview
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Target: GRM6
Tag: C-Flag&Strep Tag
Synonyms: CSNB1B, GPRC1F, MGLUR6, mGlu6
Protein Families: Transmembrane, Druggable Genome
Protein Pathways: GPCRDB Class C Metabotropic glutamate pheromonePlease contact us at for specific academic pricing.
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Mutations in this gene result in congenital stationary night blindness type 1B. [provided by RefSeq, May 2018]
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- Properties
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Overview
Human GRM6-Strep full length protein-synthetic nanodisc
Human GRM6-Strep full length protein-synthetic nanodisc
Catalog Number:
P001561628DIM
Mfr. No.:
FLP120326
Price:
$911
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