Human GPBAR1-Strep full length protein-synthetic nanodisc

Human GPBAR1-Strep full length protein-synthetic nanodisc

Catalog Number:
P001561630DIM
Mfr. No.:
FLP120287
Price:
$911
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      • Overview

        • Target: GPBAR1
          Tag: C-Flag&Strep Tag
          Synonyms: BG37, GPCR19, GPR131, M-BAR, TGR5
          Protein Families: Druggable Genome

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          Background

          This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length GPBAR-Strep protein has a MW of 35.2 kDa
          Expression system
          HEK293

          More Information

          UniProt
          Q8TDU6

          * For research use only.

    MSDS

    Documents

    Datasheet

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