Human FZD7 full length protein-synthetic nanodisc

Human FZD7 full length protein-synthetic nanodisc

Catalog Number:
P001561734DIM
Mfr. No.:
FLP100109
Price:
$1,013
  • Size:
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • Target: FZD7
          Tag: C-Flag Tag
          Synonyms: FzE3
          Protein Families: Druggable Genome, Transmembrane
          Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway

          Please contact us at for specific academic pricing.

          Background

          Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length FZD7 protein has a MW of 63.6 kDa
          Expression system
          HEK293

          More Information

          UniProt
          O75084

          * For research use only.

    MSDS

    Documents

    Datasheet

    We Also Recommend

    Human MFSD13A full length protein-synthetic nanodisc

    Human MFSD13A full length protein-synthetic nanodisc

    $1,013

    Human NPC1L1 full length protein-synthetic nanodisc

    Human NPC1L1 full length protein-synthetic nanodisc

    $1,013

    Human TMCC3 full length protein-synthetic nanodisc

    Human TMCC3 full length protein-synthetic nanodisc

    $1,013