Human Factor Related Apoptosis Ligand ELISA Kit (FASL)

Tumor Necrosis Factor Ligand Superfamily Member 6; Apoptosis Antigen Ligand; Aptl; Cd95 Ligand; Cd95-L; Fas Antigen Ligand; Fas Ligand; Fasl; Cd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form; Receptor-Binding Fasl Ectodomain; Soluble Fas Ligand; Sfasl - Adam10-Processed Fasl Form; Apl - Fasl Intracellular Domain; Fasl Icd; Sppl2a-Processed Fasl Form; Spa

Uniprot ID: NMDE1_HUMAN ; Reactome: R-HSA-140534 ; Gene ID: 356 ; Gene Symbol: FASLG

Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process. FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition.