Human DLD (Dihydrolipoyl Dehydrogenase) CLIA Kit

Dihydrolipoyl Dehydrogenase - Mitochondrial; Dihydrolipoamide Dehydrogenase; Glycine Cleavage System L Protein

Uniprot ID: SAA4_HUMAN ; Reactome: R-HSA-204174 ; Gene ID: 1738

Function: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.