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Overview
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This DKK2 CLIA Kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
Please contact us at for specific academic pricing.
Target Information
Target NameDickkopf-Related Protein 2; Dickkopf-2; Dkk-2; Hdkk-2Database LinksUniprot ID: S10A8_HUMAN ; Reactome: R-HSA-201681 ; Gene ID: 27123About TargetTissue Specificity: Expressed in heart, brain, skeletal muscle and lung.
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
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