Human DKK4 (Dickkopf Related Protein 4) CLIA Kit

Dickkopf-Related Protein 4; Dickkopf-4; Dkk-4; Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form

Uniprot ID: S10A9_HUMAN ; Reactome: R-HSA-201681 ; Gene ID: 27121

Tissue Specificity: Expressed in cerebellum, T-cells, esophagus and lung.

Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.