Human CLPTM1 full length protein-synthetic nanodisc

Human CLPTM1 full length protein-synthetic nanodisc

Catalog Number:
P001561733DIM
Mfr. No.:
FLP100110
Price:
$1,013
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      • Overview

        • Target: CLPTM1
          Tag: C-Flag Tag
          Synonyms: N.A.
          Protein Families: Transmembrane
          Protein Pathways: N.A.

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          Background

          Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length CLPTM1 protein has a MW of 76.1 kDa
          Expression system
          HEK293

          More Information

          UniProt
          O96005

          * For research use only.

    MSDS

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