Human CLDN3 full length protein-synthetic nanodisc

Human CLDN3 full length protein-synthetic nanodisc

Catalog Number:
P001561744DIM
Mfr. No.:
FLP100078
Price:
$1,013
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      • Overview

        • Target: CLDN3
          Tag: C-Flag Tag
          Synonyms: C7orf1; CPE-R2; CPETR2; HRVP1; RVP1
          Protein Families: Druggable Genome, Transmembrane
          Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

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          Background

          Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length CLDN3 protein has a MW of 23.3 kDa
          Expression system
          HEK293

          More Information

          UniProt
          O15551

          * For research use only.

    MSDS

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