Name: Human CD45 [HI30] Monoclonal Antibody
Price: 200.00 USD

Overview
- Sensitivity: Endogenous
  Target name: Human CD45 [HI30] monoclonal antibody
  Area: Immunology/Neuroscience/Cell Markers/Microglia
  
  Please contact us at for specific academic pricing.
  
  Background
  
  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Properties
- Host
  
  Mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  Human
  
  Clone
  
  mAb
  
  Storage
  
  Long time storage is recommended at -20°C
  Phosphate-buffered solution, pH 7.2, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
  Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
  
  * For research use only.