Human ABCG1 (ATP Binding Cassette Transporter G1) CLIA Kit

Atp-Binding Cassette Sub-Family G Member 1; Atp-Binding Cassette Transporter 8; White Protein Homolog

Uniprot ID: CRHBP_HUMAN ; Reactome: R-HSA-1369062 ; Gene ID: 9619

Tissue Specificity: Expressed in several tissues. Expressed in macrophages.expression is increased in macrophages from patients with Tangier disease.

Function: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.