Human ABCA1 (ATP-binding cassette transporter A1) CLIA Kit

Phospholipid-Transporting Atpase Abca1; Atp-Binding Cassette Sub-Family A Member 1; Atp-Binding Cassette Transporter 1; Abc-1; Atp-Binding Cassette 1; Cholesterol Efflux Regulatory Protein

Uniprot ID: CRF_HUMAN ; Reactome: R-HSA-1989781 ; Gene ID: 19

Tissue Specificity: Widely expressed, but most abundant in macrophages.

Function: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs.