HRP-MMAE (1:1) Conjugate

MMAE (monomethyl auristatin E) is an antimitotic agent that binds tubulin and inhibits the assembly of microtubules. Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that contains a cathepsin clevable valine-citruline p-aminobenzylcarbamate linkage. Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin (Seattle Genetics). This HRP-MMAE conjugate is designed with similar linker chemistry as ADC and is synthesized for our customers' usage in horseradish peroxidase (HRP) based assay. A long flexible PEG linker is also incorporated in the conjugate to retain the activity of HRP and MMAE binding.

The final conjugate is purified to obtain a single MMAE-labeled HRP conjugate, and is lyophilized from PBS containing sugar-based stabilizer for easy shipping and storage.

• Chemical Information
Chemical name: HRP-MMAE (horseradish peroxidase-monomethyl auristatin E) (1:1) Conjugate
Chemical formula: N/A
Molecular weight: 44KDa CAS number: N/A

• Specification
Physical appearance: brownish preservative-free lyophilized powder in a 1.5 mL centrifuge tube
Storage temp.: at or below -20 °C
Purity: ≥ 99 % of single MMAE-labeled conjugates by HPLC
Activity: ≥110 units/mg protein [Unit Definition: one unit is the amount of enzyme that will form 1.0 mg purpurogallin from pyrogallol in 20 sec. at pH 6.0 at 20°C]
Drug to HRP ratio: 1

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