HMGB2 , LPS-free and tested in migration assay

- Overview
  - HMGB2 is 80% identical to HMGB1 protein, but is encoded by a different gene. It consists of 195 amino acids and has a calculated molecular mass of approximately 22.3 kDa.
    
    The sequence of this product is identical to Homo sapiens.
    
    It contains only trace amounts of LPS (<0.4 ng/mg protein) and it is tested for the ability to induce fibroblast migration.
    
    It has the sequence:
    ["MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG SKKKNEPEDE EEEEE" ]
    
    Purity: The purified protein is >95% homogeneous (electrophoresis). It contains no nucleic acids.
    Endotoxin Level: The purified protein is free from LPS (Pierce™ Chromogenic Endotoxin Quant Kit, <0.1 EU/mL). The product contains <0.006% v/v of Triton X-114 due to LPS removal procedure. The remaining traces of Triton X-114 can be removed upon request.
    Buffer & Reconstitution: the lyophilized protein once reconstituted with distilled water will be dissolved in a solution containing 50 mM HEPES pH 7.9, 500 mM NaCl and DTT 0,5mM
    Storage: the protein is shipped lyophilized. Once resuspended can be stored frozen at -20°C. To avoid cysteine oxidation, DTT 0.5mM is added during protein purification.
    
    Please contact us at for specific academic pricing.
- Properties
  - Type
    
    Recombinant Proteins
    
    * This product is intended for research only, and cannot be used on humans.
- Reference
  - HMGB2 causes photoreceptor death via down-regulating Nrf2/HO-1 and up-regulating NF-κB/NLRP3 signaling pathways in light-induced retinal degeneration model
    Molecular cloning and functional characterization of HMGB1 and HMGB2 in large yellow croaker Larimichthys crocea
    Single-cell dissection reveals the role of DNA damage response patterns in tumor microenvironment components contributing to colorectal cancer progression and immunotherapy
    Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway
    Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone Heteractis magnifica
    New Insights into the Role of HMGB2 in ST-Segment Elevation Myocardial Infarction
    HMGB2 upregulation promotes the progression of hepatocellular carcinoma cells through the activation of ZEB1/vimentin axis
    Ionizing radiation induces vascular smooth muscle cell senescence through activating NF-κB/CTCF/p16 pathway
    HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF- κβ Pathway
    Identification of aging-related genes in diagnosing osteoarthritis via integrating bioinformatics analysis and machine learning
    Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
    Exploring HMGB2 in hepatocellular carcinoma: charting new paths for diagnostic and therapeutic innovations
    Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells
    Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions
    Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2
    PfHMGB2 has a role in malaria parasite mosquito infection
    Duck HMGB2 Mediates Signaling Pathways in the Innate Immunity of Hosts Against Viral Infections
    IKBKE promotes the ZEB2-mediated EMT process by phosphorylating HMGA1a in glioblastoma
    Microglia nuclear receptor corepressor 1 deficiency alleviates neuroinflammation in mice
    Aucubin protects against myocardial ischemia-reperfusion injury by regulating STAT3/NF-κB/HMGB-1 pathway
    GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma
    MiR-2113 overexpression attenuates sepsis-induced acute pulmonary dysfunction, inflammation and fibrosis by inhibition of HMGB1
    Therapeutic effects of anti-diabetic drugs on traumatic brain injury
    MicroRNA-146a gene transfer ameliorates senescence and senescence-associated secretory phenotypes in tendinopathic tenocytes
    Toxoplasma gondii Infection Induces High Mobility Group Box 1 Released from Mouse Macrophages
    HMGA2 promotes nasopharyngeal carcinoma progression and is associated with tumor resistance and poor prognosis
    The IGF2BP2-lncRNA TRPC7-AS1 axis promotes hepatocellular carcinoma cell proliferation and invasion
    High Mobility Group Proteins in Sepsis
    High mobility group A proteins as tumor markers
    The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury
    The Role of High Mobility Group Box 1 in Ischemic Stroke
    [High mobility group nucleosome binding protein 1 (HMGN1) induces activation of mouse BV2 microglia and upregulates their pro-inflammatory mediator expression by activating TLR4/MyD88/NF-κB p65/IKK-β signal pathway]
    Citrullinated isomer of myelin basic protein can induce inflammatory responses in astrocytes
    Propranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6
    Ronfani et al (2001) Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development 128:1265-73