Non-oxidizable HMGB1 , LPS free

This product is a mutant protein where all cysteines are replaced with serines. Non-oxidizable chemokine-HMGB1, LPS free, has chemoattractant activity in vitro and in vivo, does not have cytokine-inducing activity and is resistant to inactivation by ROS (Venereau et al, 2012). This product is produced in E.coli. It contains only trace amounts of LPS (<0.4 ng/mg protein), and is tested for the ability is tested for the ability to induce fibroblast migration.

Reagent format: Non-oxidizable chemokine-HMGB1 is lyophilized from 50 mM HEPES buffer pH 7.9, 500 mM NaCl and 0.5 mM DTT.
Storage: 2-8°C. The protein once resuspended can be stored frozen (-20°C).
How to use product: The product can be used to recruit leukocytes in vivo without inducing cytokine/chemokine production (Venereau et al, 2012).

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