Hexanolamino PAF C-16

- Overview
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    Background
    
    Hexanolamino PAF C-16 is a PAF analog with PAF agonist/antagonist properties. Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages [1]. Hexanolamino PAF C-16, a PAF analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. In human monocyte-derived macrophages, Hexanolamino PAF C-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (H202) in response to PAF [1]. In both rabbit platelets and guinea-pig macrophages, Hexanolamino PAF C-16 acted as a partial agonist [2].
    
    [1]. Rouis M, Nigon F, Chapman MJ. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun. 1988 Nov 15;156(3):1293-301.
    [2]. Stewart AG, Grigoriadis G. Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat. 1991 Nov;4(3):299-308.
- Properties
  - Categories
    
    a PAF analog with mixed agonist/antagonist properties
    
    Alternative Name
    
    1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl(N,N,N-trimethyl)hexanolamine
    
    CAS Number
    
    137566-83-7
    
    Molecular Formula
    
    C30H62NO7P
    
    Molecular Weight
    
    579.8
    
    Appearance
    
    A lyophilized powder
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCCCCCCCCCCCCCCCOC[[email protected]@H](OC(C)=O)COP(OCCCCCC[N+](C)(C)C)([O-])=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Hexanolamino PAF C-16

Background

Documents

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