Name: Hexa-D-arginine
Price: Inquiry

- Overview
  - Furin inhibitor.
    Hexa-D-arginine is an inhibitor of furin, with Ki values of 106 nM, 580 nM and 13.2 μM for furin, PACE4 and PC1 respectively. Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity and hexa-d-arginine effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and decreases circulating levels of tumour necrosis factor alpha. Hexa-D-arginine also blocks furin mediated SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
    
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- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    Hexa-d-arginine amide, D6R, Furin Inhibitor II
    
    Molecular Formula
    
    C36H75N25O6
    
    Molecular Weight
    
    954.16
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble to 2 mg/ml in water
    
    Other Properties
    
    Sequence: H-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-NH2,rrrrrr-NH2
    Modification: C-terminal amide, arginines 1,2,3,4,5 and 6 are all D- configuration
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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