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Herbimycin A [CAS 70563-58-5]

Herbimycin A [CAS 70563-58-5]

Catalog Number:

CR04341424TOK

Mfr. No.:

TOK-H002

Price:

$430

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Quantity:

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- Overview
  - Herbimcyin is a sparingly soluble benzoquinone anti-tumor agent which interacts with the stress-induced chaperone protein Hsp90 (heat shock protein 90).
    
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    Background
    
    Herbimycin A binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response.
- Properties
  - CAS Number
    
    70563-58-5
    
    Molecular Formula
    
    C30H42N2O9
    
    Molecular Weight
    
    574.66
    
    Appearance
    
    Yellow powder
    
    Solubility
    
    DMSO: Soluble
    
    Other Properties
    
    Source: Streptomyces hygroscopicus
    Purity Level: (HPLC): ≥95.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: In normal cells, Hsp90 stabilizes and folds proteins, however, in tumor cells, Hsp90 activity helps stabilize mutated growth factor and signal proteins which facilitate tumor growth. To prevent this complication, Herbimycin A binds to and inactivates Hsp90 in cancerous cells leading to degradation of cancer cell proteins.

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