H_DPP4 HEK-293T Cell Line

DPP4 protein, also known as CD26, is a membrane-associated protein. It is an enzyme located on the cytoplasm and cell membrane, primarily catalyzing the hydrolysis of dipeptides by cleaving two amino acid residues from the NH2-terminus. DPP4 is widely expressed in human tissues, with particularly high levels found in the small intestine, liver, lungs, spleen, and kidneys. In addition to its enzymatic activity, DPP4 plays an important role in immune regulation, cell adhesion, signal transduction, and tumor growth.

MERS-CoV is a coronavirus that uses DPP4 on the surface of human cells as its receptor to invade host cells. The virus binds to DPP4, entering epithelial cells and causing the symptoms of Middle East Respiratory Syndrome (MERS).

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