Name: GT1b-Oligosaccharide
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- Overview
  - GT1b oligosaccharide (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, and sialic acid (NeuAc) linked α2,3 to the terminal galactose residue (Ledeen, 2009). The GT1b ganglioside is one of the major gangliosides in neuronal and glial membranes; it interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishiki, 1996), as well as for viruses. A few examples of which include: Merkel cell polyomavirus, JC virus, BK virus, norovirus and others (Low, 2006).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    CAS Number
    
    75663-36-4
    
    Molecular Formula
    
    C59H96N4O45
    
    Molecular Weight
    
    1,581.39 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
    Nishiki et al (1996) The high‐affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a, Febs Letters, 378(3), 253-257
    Low et al (2006) Identification of Gangliosides GD1b and GT1b as Receptors for BK Virus, Journal of Virology, 80(3), 1361-1366