GSK-J1 (cell impermeable)

GSK-J1 (cell impermeable)

Catalog Number:
I001528162REA
Mfr. No.:
EI-DEM-001
Price:
$288
  • Size:
    5 mg
    Quantity:
    Add to Cart:
      • Overview
        • N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-b-alanine

          GSK-J1 is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog (GSK-J4) is also available.

          Please contact us at for specific academic pricing.

      • Properties
        • Molecular Formula
          C22H23N5O2
          Molecular Weight
          MW=389.5
          Appearance
          Pale yellow powder
          Solubility
          Solubilization: May be dissolved in DMSO (20 mg/ml, warm)
          Storage
          Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

          * For Research Use Only.

      • Applications
        • Application
          Epigenetic Inhibitors

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