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Overview
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N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-ß-alanine ethyl ester
GSK-J4 is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 µM for the inhibition of TNFa release). Cell permeable, ethyl ester of GSK-J1. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. Inhibits the growth of T-cell acute lymphoblastic leukemia (T-ALL) cells.Please contact us at for specific academic pricing.
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Overview