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GSK-J4 (cell permeable)

GSK-J4 (cell permeable)

Catalog Number:
I001528163REA
Mfr. No.:
EI-DEM-002
Price:
$297
  • Size:
    5 mg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-ß-alanine ethyl ester

          GSK-J4 is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 µM for the inhibition of TNFa release). Cell permeable, ethyl ester of GSK-J1. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. Inhibits the growth of T-cell acute lymphoblastic leukemia (T-ALL) cells.

          Please contact us at for specific academic pricing.

      • Properties
        • Molecular Formula
          C24H27N5O2
          Molecular Weight
          MW=417.5
          Appearance
          Yellow wax
          Solubility
          Solubilization: May be dissolved in DMSO (40 mg/ml); or ethanol (40 mg/ml)
          Storage
          Store, as supplied, at -20°C. Store solutions at -20°C for up to 3 months.

          * For Research Use Only.

      • Applications
        • Application
          Epigenetic Inhibitors

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