Name: GM2-Ganglioside
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- Overview
  - GM2 ganglioside (sodium salt) has a core trisaccharide structure (GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the central galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumours of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of the GM2 ganglioside is a receptor allowing the viral infection of cells with reovirus and rotavirus (Zhu, 2018).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    Monosialoganglioside GM2;b-GalNAc-(1?4)-[a-Neu5Ac-(2?3)]-b-Gal(1?4)-b-Glc-(1?1)-Cer
    
    CAS Number
    
    19600-01-2
    
    Molecular Formula
    
    C67H121N3O26
    
    Molecular Weight
    
    1,384.68 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J) pp 495-516, Wiley-VCH, Weinheim
    Cachon-Gonzalez et al (2018), Genetics and Therapies for GM2 Gangliosidosis, Current Gene Therapy, 18(2), 68-89
    Yoshida et al (2020), B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2, Scientific Reports, 10, 1199.
    Zhu et al (2018), Both ganglioside GM2 and cholesterol in the cell membrane are essential for Bombyx mori cypovirus cell entry, Developmental&Comparative Immunology, 88, 161-168,

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