Name: GM1-Pentasaccharide
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- Overview
  - GM1 pentasaccharide (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with a single sialic acid residue linked α2,3 to the inner galactose residue (Ledeen, 2009). GM1 pentasaccahride is the carbohydrate moiety of GM1 ganglioside. GM1 ganglioside interacts and modulates tyrosine kinases, such a,s neural tropomyosin receptor kinase A (TrkA), by inducing the release of neurotrophins from fibroblast cells and the epidermal growth factor receptor (EGFR) (Higuero, 2009). GM1 ganglioside is also found in epithelial membranes; it is a key element for bacterial toxicity and viral infection as it acts as a receptor for the B-subunits of heat-labile toxin, cholera toxin, rotavirus, and simian virus 40. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    GM1-oligosaccharide
    
    CAS Number
    
    52659-37-7
    
    Molecular Formula
    
    C37H62N2O29
    
    Molecular Weight
    
    998.88 g/mol
    
    MDL Number
    
    MFCD29045287
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J) pp 495-516, Wiley-VCH, Weinheim
    Higuero et al (2017) The sugar code in neuronal physiology. Histochem Cell Biol 147, 257-267.
    Chiricozzi et al (2020) GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration, International Journal of Molecular Sciences, 21(3), 868.

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