Name: GM1-Ganglioside ammonium
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- Overview
  - GM1 ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009) and is abundant in all mammalian brains, where it covers 10%–20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020). The functional significance of ammonia in the brain is not yet fully understood: see (Modi, 1994).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    CAS Number
    
    37758-47-7
    
    Molecular Formula
    
    C73H131N3O31·xNH4
    
    Molecular Weight
    
    1,563.9 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use