GM-CSF, murine recombinant

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Background

Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system. GM-CSF is mainly produced by activated T cells, B cells, macrophages and mast cells. GM-CSF plays an important role in stimulating the survival, proliferation, differentiation and activation of hematopoietic cells such as granulocytes and monocytes, basophiles and eosonophoiles, neutrophiles, erythroid cells, megakaryocytes and T cells.
Murine GM-CSF is a 141 amino acids glycoprotein. Human and mouse GM-CSF are species specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.0 kDa protein containing 124 amino acid residues.