IFN-gamma, murine recombinant

Please contact us at for specific academic pricing.

Background

Interferon-gamma (IFN-γ) is a prototype proinflammatory cytokine that is mainly produced by activated T, B and NK cells. IFN-γ exists immunoregulatory activities, anti-viral activities, anti-proliferative and proinflammatory activities. IFN-γ can also upregulate MHC class I and II antigen expression by antigen-presenting cells. IFN-γ plays a key role in host defense by promoting the development and activation of Th1 cells, up-regulation of antigen presentation molecules, chemoattraction and activation of monocytes and macrophages and immunoglobulin class switching in B cells. In addition, IFN-γ functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation.
Mature mouse IFN-γ exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits. Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.