Germicidin B

- Overview
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    Background
    
    Germicidin is a pyranone antibiotic originally excreted by Streptomyces viridochromogenes NRRL B-1551. Germicidin has an inhibitory effect on the germination of its own arthrospores at a concentration as low as 200 pM (40 pg/ml). Higher concentrations of germicidin inhibited porcine Na+/K+-activated ATPase and retarded the germination of the cress Lepidium sativum with an ID50 of 100 μM. Germicidin was the first known autoregulative inhibitor of spore germination in the genus Streptomyces and was isolated from the supernatant of germinated spores, but also from the supernatant of the submerged culture [1].
    Germicidins B inhibited germination of S. coelicolor A3(2) spores above 1 μg/ml. The S. coelicolor A3(2) spores collected from a single petri dish (9 cm i.d.) contained 5.4 μg of germicidin A (~2.7 × 10-14 g per spore) and contents of germicidins B, C and D were 0.2–0.8 μg. The activity of the spore extract corresponded well with the sum of the activity of each germicidin. Germicidins functioned as self-germination inhibitors in S. coelicolor A3(2) [2].
    
    [1] PETERSEN F, ZHNER H, METZGER J W, et al. Germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551[J]. The Journal of antibiotics, 1993, 46(7): 1126-1138.
    [2] Aoki Y, Matsumoto D, Kawaide H, et al. Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3 (2)[J]. The Journal of antibiotics, 2011, 64(9): 607-611.
- Properties
  - Categories
    
    pyranone antibiotic
    
    Alternative Name
    
    3-ethyl-4-hydroxy-6-(1-methylethyl)-2H-pyran-2-one
    
    CAS Number
    
    150973-78-7
    
    Molecular Formula
    
    C10H14O3
    
    Molecular Weight
    
    182.2
    
    Appearance
    
    A solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1OC(C(C)C)=CC(O)=C1CC
    
    * For Research Use Only