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GDC-0068 (RG7440, Ipatasertib)

GDC-0068 (RG7440, Ipatasertib)

Catalog Number:
I002097653UBP
Mfr. No.:
F6170
Price:
$260
  • Size:
    5 mg
    Quantity:
    Add to Cart:
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      • Overview

        • GDC-0068 (RG7440 or Ipatasertib) is a novel, ATP-competitive Akt1/2/3 inhibitor with IC50 values of 5 nM, 18 nM and 8 nM, respectively. GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by PI3K/Akt signaling pathway, including those with defects of the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2. GDC-0068 blocks the phosphorylation of multiple downstream targets of Akt in human cancer cell lines.

          Please contact us at for specific academic pricing.

      • Properties
        • Protein Name
          Ipatasertib, (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one
          Source
          Synthetic
          Formulation
          C24H32ClN5O2
          Storage
          Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
          Molecular Weight
          458 g/mol

          * Research Use Only

    MSDS

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