Name: GD1a-Oligosaccharide
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- Overview
  - GD1a oligosaccharide is the carbohydrate moiety from the disialylated glycosphingolipid GD1a of the a-series (shown in the sodium form), a major ganglioside found in neuronal and glial membranes. GD1a oligosaccharide has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acids linked α2,3/α2,8 to the inner galactose residue, α2,3 to the outer galactose residue (Ledeen, 2009). GD1a ganglioside interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GD1a ganglioside plays a role in viral infection as it is a receptor for viral glycoproteins in rotavirus and paramyxovirus 1. The hexasaccharide GD1a moiety was also found on a glycoprotein that acts as a receptor for adenovirus type 37. Additionally, GD1a ganglioside interacts with botulinum neurotoxin (BoNT) and is crucial for its entry into cells (Kolter, 2012).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    GD1aSaccharide
    
    CAS Number
    
    71494-27-4
    
    Molecular Formula
    
    C48H79N3O37
    
    Molecular Weight
    
    1,290.14 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J) pp 495-516, Wiley-VCH, Weinheim
    Kolter et al (2012), Review Article, Ganglioside Biochemistry ISRN Biochemistry Volume, 1-36