Name: Gangliotriose
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- Overview
  - Gangliotriose is the core trisaccharide structure in gangliosides, such as, GD2 (GalNAcβ1,4Galβ1,4Glc) (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that posess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    Asialo-GM2-trisaccharide;N-Acetylgalactosamine b1-4 Lactose;Asialo GM2 oligosaccharide;GalNAc(b1-4)Gal(b1-4)Glc
    
    CAS Number
    
    1355005-58-1
    
    Molecular Formula
    
    C20H35NO16
    
    Molecular Weight
    
    545.49 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
    Fleurence et al (2017) Review Article, Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy, Journal of Immunology Research Volume 2017, 16 pages