Ganciclovir ReadyMade™ Solution

- Overview
  - Ganciclovir ReadyMade™ Solution is provided as a sterile-filtered solution formulated in DMSO at a concentration of 2.55 mg/ml. Ganciclovir is an antiviral agent derived from guanine, and is an oxopurine and member of the 2-aminopurines. It is a synthetic analog of 2'-deoxy-guanosine that was patented in 1980. It is active against cytomegalovirus (CMV) and is used in immunology studies. In vivo, it is used in organ transplant applications.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Ganciclovir is first phosphorylated to Ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97. After that, cellular kinases convert this molecule to ganciclovir-5'-triphosphate which specifically targets cytomegalovirus (CMV) DNA polymerase since it is a competitive inhibitor of dGTP thus it gets incorporated into DNA and and inhibits viral DNA polymerases more than the cellular DNA polymerases, resulting in termination of viral DNA elogation.
- Properties
  - CAS Number
    
    82410-32-0
    
    Molecular Formula
    
    C9H13N5O4
    
    Molecular Weight
    
    255.23
    
    Other Properties
    
    Source: Synthetic
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Microbiology Applications: Ganciclovir can be used in a cell-free assay for herpesvirus type-1.
    Ganciclovir is commonly used in suceptibility testing for cytomegalovirus (CMV). A rapid phenotypic susceptibility assay was used to detect resistance to Ganciclovir and found that in one study, a strain of CMV became resistant after only 1 month. Thus, the assay of CMV susceptibilty to Ganciclovir could be very helpful in clinical applications (de Oñar, 2002).
    Several mutations in UL97 appear to be common markers for Ganciclovir resistance, and their detection may be a rapid alternative to conventional cell culture susceptibility testing for cytomegalovirus (CMV).
    
    Eukaryotic Cell Culture Applications: Human trabecular meshwork (TM) cells support CMV replication and this model system can be used to study the ocular disease uveitis. When TM cells were exposed to Ganciclovir, a concentration of 10 umol of the compound was found to significantly reduce the accumulation of viral DNA (Choi et al, 2017).