Galiellalactone

- Overview
  - Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator.
    
    Galiellalactone is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    
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    Background
    
    Recently Galiellalactone was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.
- Properties
  - CAS Number
    
    133613-71-5
    
    Molecular Formula
    
    C11H14O3
    
    Molecular Weight
    
    194.2
    
    Appearance
    
    White Lyophilisate
    
    Storage
    
    -20°C
    
    * For research use only