G-CSF, murine recombinant

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Background

Granulocyte colony stimulating factor (G-CSF) is a pleiotropic cytokine that is mainly produced by monocytes and macrophages upon activation by TNF-alpha and IFN-gamma and endotoxin. G-CSF plays an important role in the activation, proliferation and differentiation of hematopoietic cells of the neutrophilic granulocyte lineage and the mobilization of hematopoietic stem cells and progenitors into the blood circulation.
The murine G-CSF cDNA encodes a 208 amino acid (aa) residue precursor protein that is proteolytically cleaved to generate the 178 aa residue mature protein. Mouse G-CSF and human G-CSF show species cross-reactivity and mouse G-CSF is active on human cells. Recombinant murine G-CSF is a 19.0 kDa protein consisting of 179 amino acid residues.