Fmoc-N-amido-dPEG®₄-TFP ester

Fmoc-N-amido-dPEG®4-TFP ester, product number 11000, is a Fluorenylmethyloxycarbonyl-protected amino-dPEG®-acid that is pre-activated as the 2,3,5,6-tetrafluorophenyl (TFP) ester for efficient conjugation to amines. The dPEG®4 spacer allows the introduction of a short, hydrophilic spacer. Although designed for peptide synthesis, Fmoc-N-amido-dPEG®4-TFP ester can be used in numerous applications.

PEGylation with dPEG® Products
PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs.

PEG is amphiphilic. Consequently, peptide synthesis often employs PEGylation to enhance the water solubility of hydrophobic peptides. Moreover, PEGylation prolongs the in vivo circulation of peptide conjugates by increasing the peptide's hydrodynamic volume and protecting the peptide from proteolysis. Furthermore, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

However, traditional PEGs are dispersed polymers (Đ > 1.00). A traditional PEG consists of multiple chain lengths with various molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Oursingle molecular weight PEG products (known as "discrete PEG" and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headaches that come from having an intractable mixture of conjugates, each with different PEG chain lengths.

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