Fmoc-N-amido-dPEG®₈-TFP ester

Fmoc-N-amido-dPEG®8-TFP ester, product number 11005, is an amino-dPEG®-acid. A Fluorenylmethyloxycarbonyl (Fmoc) group protects the N-terminus of the product. A 2,3,5,6-tetrafluorophenyl (TFP) ester functionalizes the C-terminus for efficient conjugation to a peptide chain. Fmoc-N-amido-dPEG®8-TFP ester is designed to facilitate the introduction of a medium-length, hydrophilic spacer into a peptide chain. However, it can find extensive use in other applications.

PEGylation with dPEG® Products
PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs.

Because PEG is amphiphilic, peptide synthesis often employs PEGylation to enhance the water solubility of hydrophobic peptides. Moreover, peptide PEGylation (1) prolongs the in vivo circulation of conjugates by increasing the conjugate's hydrodynamic volume, (2) protects the peptide from proteolysis, and (3) reduces or eliminates the antigenicity of the conjugated peptide.

However, traditional PEGs are dispersed polymers (Đ > 1.00). A traditional PEG consists of multiple chain lengths with various molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Oursingle molecular weight PEG products (known as "discrete PEG" and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headaches that come from having an intractable mixture of conjugates, each with different PEG chain lengths.

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