Fmoc-N-amido-dPEG®₂-acid

Fmoc-N-amido-dPEG®2-acid, product number 10243, is one of Quanta BioDesign's peptide synthesis products. The dPEG®2 spacer allows the introduction of a short, hydrophilic spacer into a peptide chain. The Fmoc protecting group can be removed using standard peptide chemistry.

PEGylation and dPEG® Products
PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis frequently employs PEGylation to enhance the solubility of the peptide, because the amphiphilic character of PEG imparts tremendous water solubility to peptides. Moreover, peptide PEGylation prolongs in vivo circulation of peptide conjugates by both increasing the peptide's hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

Traditional PEGs, however, are dispersed polymers (Đ > 1). A traditional PEG consists of multiple different chain lengths with various molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Oursingle molecular weight PEG products (known as "discrete PEG" and sold under the dPEG® trademark) have no dispersity (Ð = 1). Our products provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths.

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