FITC-labeled Fibrinogen

FITC-labeled Fibrinogen

Catalog Number:
E001055327ZED
Mfr. No.:
F006
Price:
$489
  • Size:
    5 mg
    Quantity:
    Add to Cart:
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      • Overview

        • Please contact us at for specific academic pricing.

          Background

          Fibrinogen (factor I) is a plasma glycoprotein that is converted by thrombin into fibrin by cleaving fibrinopeptides A+B during blood coagulation. Fibrin forms the blood clot and is subsequently cross linked by factor XIIIa. Human fibrinogen is a hexamer composed of three pairs of chains (α2β2γ2) with a molecular weight of 340 kDa.

      • Properties
        • Source
          Human
          Storage
          Storage for several months is possible at ≤ - 20°C. Delivery is possible at ambient temperature
          Note
          INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.
          Class
          Protein Substrates
          Reconstitution
          Add at least the volume of H2O the protein is lyophilized from (see Certificate of Analysis) to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in working aliquots.
          Activity
          Ca2+, Thrombin
      • Applications
        • Application Description
          The FITC-labelled fibrinogen may be used as substrate for FXIII in a crosslinking reaction. The crosslinking of fibrin followed by fibrinolysis gives information about clot-rigidity and therefore about the degree of clot-formation catalysed by FXIII.
      • Reference

        • Mutch et al., J Thromb Haemost. 2010, 8:2017-24

    Datasheet
    MSDS

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