FGF-21, murine recombinant

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Background

Fibroblast growth factor 21 (FGF-21) is a member of the FGF family that contains more than 20 small (~17–26 kDa) secreted peptides. FGF-21 is mainly secreted by the liver and can travel through the circulatory system and function as an endocrine hormone. FGFs modulate cellular activity via 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, -4 and -5. FGFRs play an important role in the regulation of glucose and lipid homeostasis. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity, and lowers blood glucose and triglyceride levels in diabetic rodents.
Mouse FGF-21 is a 210 amino acid (aa) polypeptide that contains a 120 aa core FGF domain and a hydrophobic N-terminus signal sequence that is cleaved to release the soluble 180 aa mature FGF-21 protein. Recombinant mouse FGF-21 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal Methionine. The amino acid sequence of the recombinant mouse FGF-21 is 100% homologous to the amino acid sequence of the mouse FGF-21 without signal sequence. The FGF-21 is purified by proprietary chromatographic techniques.