Erythromycin Thiocyanate

- Overview
  - Erythromycin Thiocyanate is the thiocyanate form of the broad-spectrum macrolide antibiotic Erythromycin. It was discovered in 1952 from Saccharopolyspora erythraea (formerly Streptomyces erythraeus). Erythromycin acts by inhibiting bacterial protein synthesis.
    
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    Background
    
    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to erythromycin is commonly attributed to mutations in 50S rRNA preventing erythromycin binding allowing the cell to synthesize proteins free of error. Erythromycin is also a splicing inhibitor of eukaryotic nuclear pre-mRNA, almost completely inhibiting the formation of the splicing-active C complex.
- Properties
  - CAS Number
    
    7704-67-8
    
    Molecular Formula
    
    C37H67NO13 • HSCN
    
    Molecular Weight
    
    793.02
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    Soluble in ethanol
    
    Other Properties
    
    Source: Saccharopolyspora erythraea (formerly Streptomyces erythraeus)
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Effective against Gram-positive bacteria, Gram-negative bacteria, and Mycoplasma.
    
    Microbiology Applications: Erythromycin Thiocyanate has an antibacterial spectrum similar to benzylpenicillin. It is effective for S. aureus including penicillin-resistant staphylococcus, streptococci, and pneumoniae.