Erythromycin Ethylsuccinate

- Overview
  - Erythromycin Ethylsuccinate is a broad-spectrum macrolide antibiotic produced by Streptomycin erythreus. The compound is an ester of erythromycin base and succinic acid. Erythromycin Ethylsuccinate can act as an enzyme inhibitor, and can down-regulate motilin receptors. It is freely soluble in organic solvents.
    
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    Background
    
    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to Erythromycin is commonly attributed to mutations in 50S rRNA preventing erythromycin binding allowing the cell to synthesize proteins free of error. for this reason, Erythromycin Ethylsuccinate can be used to study Erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumonia.
- Properties
  - CAS Number
    
    1264-62-6
    
    Molecular Formula
    
    C43H75NO16
    
    Molecular Weight
    
    862.05 g/mol
    
    Appearance
    
    White crystalline powder
    
    Solubility
    
    Freely soluble in organic solvents. Sparingly soluble in water.
    
    Other Properties
    
    Source: Saccharopolyspora erythraea
    Water Content (Karl Fischer): <3.0%
    PH: 6.0-8.5
    Melting Point: 219-224 °C
    
    Storage
    
    ≤30°C. Protect from light
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Erythromycin is a broad-spectrum antibiotic commonly targeting Gram-positive and Gram-negative bacteria, with similar spectrum to penicillin. It is also effective against Mycoplasmas and can be used for M. pneumoniae. It is commonly used to target bacteria responsible for respiratory tract infections.
    
    Microbiology Applications: Erythromycin Ethylsuccinate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive, Gram-negative, and Mycoplasma species. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Mycoplasma pneumoniae 0.0019 µg/mL – 0.0078 µg/mL Legionella pneumophila 0.008 µg/mL – 1 µg/mL