Name: ERK5-in-1
Price: 821.00 USD

- Overview
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    Background
    
    ERK5-IN-1 is a potent and selective ERK5 inhibitor. In vitro, ERK5-IN-1 effectively inhibits ERK5 biochemically with an IC50 of 162 nM. In cell experiments, ERK5-IN-1 has a cellular EC50 for inhibiting epidermal growth factor induced ERK5 autophosphorylation of 0.09 μM. In cell-based analysis, it is at least 30 times more selective for ERK5 than LRRK2. It is also ERK5 selective for a group of other kinases. Available Oral Bioavailability.
- Properties
  - Alternative Name
    
    2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
    
    CAS Number
    
    1234479-76-5
    
    Molecular Formula
    
    C25H29N7O2
    
    Molecular Weight
    
    459.54
    
    Purity
    
    98%
    
    Solubility
    
    ≥100mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN(C1=CN=C(NC2=C(OC)C=C(N3CCN(C)CC3)C=C2)N=C1N(C)C4=C5C=CC=C4)C5=O
    
    * For Research Use Only