Name: BLU-554
Price: 217.00 USD

- Overview
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    Background
    
    BLU-554 is an effective, highly selective, orally active FGFR4 inhibitor with IC50 of 5 nM. The IC50 range for FGFR1-3 is 624-2203 nM. In vitro, BLU-554 interacts with FGFR4 and has high potency and selectivity for FGFR4 inhibition; in vivo, BLU-554 is well tolerated in tumor models and induces tumor regression in liver cancer models.
- Properties
  - Alternative Name
    
    Fisogatinib; N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide
    
    CAS Number
    
    1707289-21-1
    
    Molecular Formula
    
    C24H24Cl2N4O4
    
    Molecular Weight
    
    503.38
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥50.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    COC1=CC(OC)=C(Cl)C(C2=CC3=CN=C(N[[email protected]]4[[email protected]@H](NC(C=C)=O)CCOC4)N=C3C=C2)=C1Cl
    
    * For Research Use Only