Erdafitinib

Erdafitinib

Catalog Number:
FC01366351APE
Mfr. No.:
APE-B8387
Price:
$212
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      • Overview
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          Background

          Erdafitinib is an effective, selective and oral bioactive pan-fibroblast growth factor receptor FGFR inhibitor with potential anti-tumor activity and inhibits FGFR1/2/3/4 with IC50s of 1.2, 2.5, 3.0 and 5.7 nM, respectively.In vitro, Erdafitinib-treated cells reduced proliferation, increased apoptotic death, and reduced cell survival. In vivo experiments, Erdafitinib treatment delayed the growth of NCI-H716 tumors, and when drug treatment was withdrawn, tumor volume increased.

      • Properties
        • Alternative Name
          JNJ-42756493; N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine
          CAS Number
          1346242-81-6
          Molecular Formula
          C25H30N6O2
          Molecular Weight
          446.54
          Purity
          98.00%
          Solubility
          insoluble in H2O; ≥15 mg/mL in EtOH; ≥54.5 mg/mL in DMSO
          Storage
          Store at -20°C
          SMILES
          CN(N=C1)C=C1C2=NC3=CC(N(CCNC(C)C)C4=CC(OC)=CC(OC)=C4)=CC=C3N=C2

          * For Research Use Only

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