ERD-308

- Overview
  - ERD-308 (ERD308) is a highly potent PROTAC degrader of estrogen receptor (ER) with the potential for treating ER positive breast cancer treatment (DC50: 0.17 nM (ER in MCF-7 cells)). ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively). ERD-308 also induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    PROTACs
    
    CAS Number
    
    2320561-35-9
    
    Molecular Formula
    
    C55H65N5O9S2
    
    Molecular Weight
    
    1004.26
    
    Purity
    
    ≥98%
    
    Storage
    
    Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
    In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
    
    Shipping
    
    Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
    
    SMILES
    
    O=C([C@H]1N(C([C@@H](NC(COCCCCCN(CC)CCOC2=CC=C(C(C3=C(C4=CC=C(O)C=C4)SC5=CC(O)=CC=C53)=O)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
    
    * For research use only

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