(-)-Epigallocatechin gallate (EGCG)

- Overview
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    Background
    
    (-)-Epigallocatechin gallate (EGCG), the major catechin accounting for 59% of the total catechins in green tea, is a powerful antioxidant as well as an antiangiogenic and antitumor agent. EGCG has been studied for its role in the chemoprevention of a wild range of cancers, including liver, stomach, skin, lung, mammary gland and colon cancers. Study results show that EGCG is able to induce apoptosis, promote cell growth arrest and block carcinogenesis by affecting signal transduction pathways. Moreover, EGCG exhibits inhibition against a variety of viruses, including HCV, HIV-1, HBV, HSV-1, HSV-2, EBV, adenovirus, influenza virus and enterovirus, as well as several enzymes, including DNMTs, proteases and DHFR.
    
    Reference:
    Singh BN, Shankar S, Srivastava RK. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol. 2011; 82(12):1807-1821.
    Steinmann J, Buer J, Pietschmann T, Steinmann E. Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea. Br J Pharmacol. 2013; 168(5):1059-1073
- Properties
  - Categories
    
    Antioxidant, antiangiogenic and antitumor agent
    
    Alternative Name
    
    EGCG
    
    CAS Number
    
    989-51-5
    
    Molecular Formula
    
    C22H18O11
    
    Molecular Weight
    
    458.37
    
    Appearance
    
    A solid
    
    Purity
    
    99.84%
    
    Solubility
    
    ≥22.9 mg/mL in DMSO; ≥10.9 mg/mL in H2O with ultrasonic; ≥6.76 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    OC1=CC(O)=C(C[[email protected]@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)[[email protected]@H](C3=CC(O)=C(O)C(O)=C3)O4)C4=C1
    
    * For Research Use Only